The participants of this study are type 2 diabetic patients.All of the T2DM patients were ancillary to the vitamin C project
Conditions
Interventions
The type 2 diabetic patients have received 1,
000 mg vitamin C diary for 6 weeks. The change of miRNA expression was compared between pre-
vs. post-
vitamin C consumption
Experimental Dietary Supplement
Sponsors
The Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associ
The Royal Golden Jubilee (RGJ) Ph.D Programme,
The Thailand Research Fund (TRF)
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Having type 2 diabetes mellitus for at least 12 months, with poor glycemic control (HbA1c ≥8.5%), being treated with oral diabetic drugs only (no insulin injection), receiving lipid-lowing drugs or anti-hypertensive drugs, sedentary and lack of any regular exercise program for at least 6 months and living in Khon Kaen Province, Thailand. For microRNA study, Blood samples from the patients who increased plasma vitamin C levels and phagocytosis activity as well reduced oxidative stress at post-vitamin C supplementation compared to pre-supplement (results from the previous study in our lab group) were selected to investigate microRNA expression.
Exclusion criteria
Exclusion criteria: Failed to increase vitamin C levels after the vitamin C intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| circulating microRNA expression Before and after 6 weeks of the intervention microRNA microarray | — |
Secondary
| Measure | Time frame |
|---|---|
| circulating microRNA expression Before and after 6 weeks of the intervention qRT-PCR | — |
Countries
Thailand
Contacts
Public ContactLa-ongthip Ruknarong
Graduate school (Biomedical Science program), Khon Kaen University
Outcome results
None listed