Comparison of efficacy of high dose magnesium sulfate infusion versus standard dose magnesium infusion in moderate to severe asthma exacerbation in children

Status

Recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

TCTR

Registry ID

TCTR20191118001

Enrollment

Unknown

Registered

2019-11-18

Start date

2019-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

&#45

Interventions

magnesium sulfate 50 ml/kg/dose total 1 hr then high dose magnesium sulfate intravenous 50 ml/kg/dose total 4 hours,magnesium sulfate 50 ml/kg/dose total 1 hr then NSS 100 ml iv drip in 4 hours (act a

Experimental Drug,Experimental Drug

high dose magnesium sulfate intravenous ,standard dose magnesium sulfate intravenous

Eligibility

Sex/Gender

All

Age

2 Years to 15 Years

Inclusion criteria

Inclusion criteria: - Age 2-15 years - Moderate to severe asthma exacerbation (Thammasat asthma score â‰¥ 5, SpO2 < 95%) - Non respond to SABAs or anticholinergic 3 doses with systemic corticosteroid

Exclusion criteria

Exclusion criteria: - BT > 38.5 C - Hypotension < P25 - Renal, pulmonary, cardiology disease

Design outcomes

Primary

Measure	Time frame
Clinical and therapeutic responder 1-6 hr after after treatment Clinical asthma score	—

Secondary

Measure	Time frame
Adverse events 1-6 hr after after treatment Serum magnesium sulfate and blood pressure and clinical apnea	—

Countries

Thailand

Contacts

Public ContactSupinya Naruphanthawart

Faculty of medicine, Thammasart university

narsupinya077@gmail.com0850627682

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026