knee osteoarthritis knee arthroplasty knee arthroplasty parecoxib nerve block
Conditions
Interventions
A patient will receive intravenous parecoxib before surgery and every 12 hours after surgery for 3 times,A patient will receive intravenous parecoxib and perineural bupivacaine before surgery and eve
Active Comparator Drug,Active Comparator Drug,Active Comparator Procedure/Surgery
Parecoxib,Combined treatment,Peripheral nerve block
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Osteoarthritis of knee joint patients with ASA classification I-III who are scheduled for elective unilateral total knee arthoplasty
Exclusion criteria
Exclusion criteria: 1. Body mass index less than 35 kg/m2 2. Presentation of any conditions that may interfere the oxidative stress levels including any malignant diseases, any infectious diseases, neurodegenerative diseases, atherosclerotic disease, peripheral arterial disease, chronic kidney disease and active heavy smoking 3. Antioxidant use within 4 weeks 4. Glucocorticoid use within 3 months 5. Presentation of contraindications of regional anesthesia including coagulopathy and increased intracranial pressure 6. Allergy to any medications in the study protocol 7. Presentation of any conditions that may interfere clinical assessment including preoperative immobility, preoperative delirium or cognitive dysfunction 8. Perioperative blood transfusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mitochondrial oxygen consumption 30 min before surgery, 12h, 24h, and 48h after surgery Measure mitochondrial function of peripheral blood mononuclear cells isolated from blood sample | — |
Secondary
| Measure | Time frame |
|---|---|
| Mitochondrial dynamics 30 min before surgery, 12h, 24h, and 48h after surgery Measure levels of Drp1, Mfn1, Mfn2, OPA1 protein expression of blood mononuclear cells,Plasma antioxidant levels 30 min before surgery, 12h, 24h, and 48h after surgery Measure levels of superoxide dismutase and reduced glutathione in plasma,Plasma inflammatory cytokines 30 min before surgery, 12h, 24h, and 48h after surgery Measure levels of TNF-a and IL-1B in plasma,Inflammatory proteins 30 min before surgery, 12h, 24h, and 48h after surgery Measure levels of p-NFkB and NFkB protein expression of blood mononuclear cells,Mental status 1 day before surgery, postoperative day 0-2 and 4 weeks after surgery Measure for postoperative delirium using Thai version of confusion assessment method,Surgical knee pain Postoperative day 0-2 Measure postoperative pain of the operated knee using visual analogue scale,Morphine consumption Postoperative day 0-2 Measure postoperative use of intravenous morphine,Knee joint function 1 day before and 4 weeks after surgery Measure pain, stiffness and function of the knee using Thai version of WOMAC index,Cognitive function 1 day before surgery, postoperative day 0-2 and 4 weeks after surgery Measure cognitive function using Thai version of Mini-Cog screening test,Depression 1 day before surgery, postoperative day 0-2 and 4 weeks after surgery Measure for postoperative depression using Thai version of the Hamilton depression rating scale | — |
Countries
Thailand
Contacts
Public ContactPrangmalee Leurcharusmee
Faculty of Medicine, Chiang Mai University
Outcome results
None listed