Clindamycin plus conventional antibiotics for prolonging latency period in preterm premature rupture of membranes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

TCTR

Registry ID

TCTR20191112001

Enrollment

Registered

2019-11-12

Start date

2019-11-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

preterm premature rupture of membranes preterm premature rupture of membranes latency period

Interventions

1. Ampicillin 2 gm IV q 6 hr x 48 hrs then Amoxicillin(250 mg) 1 tab oral q 6 hr # 5 days 2. Erythromycin(250 mg) 1 tab oral q 8 hr # 7 days 3. Clindamycin 600 mg IV q 6 hr x 48 hrs then Clindamycin(3

Experimental Drug,Active Comparator Drug

Clindamycin plus conventional antibiotics, conventional antibiotics

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: PPROM between GA 24 to 33 weeks 6 days

Exclusion criteria

Exclusion criteria: uncertain gestational age multifetal pregnancies previous cervical surgery abnormal fetal chromosome or fetal malformation the presence of therapy with progesterone the presence of antibiotics therapy for prolonging latency period history of allergy to Penicillin, Erythromycin or Clindamycin the presence of evidence of intraamniotic infection or fetal distress active labor

Design outcomes

Primary

Measure	Time frame
time of reported rupture of membranes until time of delivery at delivery hours	—

Secondary

Measure	Time frame
maternal complication postpartum period review chart	—

Countries

Thailand

Contacts

Public ContactPrapat Wanitpongpan

Siriraj Hospital

prapatw@hotmail.com0841133225

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026