Liver steatosis chronic lead poisoning hepatotoxicity steatosis liver fibrosis hepatitis Glutathione Interleukin-
Conditions
Interventions
Participants exposed to lead for at least one year who have blood lead level equal or more than 70 mcg/dL.
Active Comparator Drug
Chronic lead poisoning
Sponsors
Unit of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University
Gastroenterological Association of Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: For Chonic lead poisoning group - Patients with blood lead level ≥ 70 µg/dl - Exposed to lead ≥ 1 year For controlled group - Patients with blood lead level < 40 µg/dl - Age-sex matched with participants
Exclusion criteria
Exclusion criteria: - Chronic HBV infection - Chonic HCV infection - Autoimmune hepatitis - Wilsons disease - Hemochromatosis - Alcohol consumption (>= 30 g/day in men, >= 20 g/day in women) - Prior known exposure to hepatotoxicity drugs within 5 years - known history of NAFLD - Diabetes Mellitus
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hepatic steatosis At the study enrollment Controlled Attenuated Parameter (CAP) from fibroscan | — |
Secondary
| Measure | Time frame |
|---|---|
| Hepatic fibrosis At the study enrollment Liver stiffness from fibroscan | — |
Countries
Thailand
Contacts
Public ContactTongluk Teerasarntipan
Chulalongkorn University
Outcome results
None listed