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Evaluation of pulp response and mineralized tissue formation after direct pulp capping with calcium-silicate based cements

Effectiveness of direct pulp capping with calcium-silicate based cements

Status
Unknown
Phases
Phase 1Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20191103001
Enrollment
36
Registered
2019-11-03
Start date
2018-10-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulp exposure Direct pulp capping Dentin bridge Dentin bridge formation Reparative dentin Vital pulp therapy Direct Pulp capping Mineral Trioxide Aggregate Biodentine Dentin bridge formation Reparative dentin

Interventions

Biodentine will be prepared according to the manufacturer&#039
s instructions and used to fill half the cavity with a thickness of 1.5 to 2 mm. The layer of the different experimental materials will be placed over the pulp exposure measured 2x2 mm approximately.
s instructions . MTA will be applied onto exposed pulp tissue and adjacent dentine at a thickness of 1.5 to 2 mm. The layer of the different experimental materials will be placed over the pulp exposu
Experimental Drug,Experimental Drug

Sponsors

University of Medicine and Pharmacy at Ho Chi Minh city
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1st or 2nd permanent premolars Caries-free/ intact or small caries in enamel Apex closed, no periapical changes (apical radiograph) No periodontal pockets deeper than 4mm Medical history non-contributory No medication (no antibiotics during last month) No signs or symptoms more severe than reversible pulpitis Positive response to cold test or electrical pulp test Written consent Inclusion requires compliance with all the criteria listed patients willing to participate in study

Exclusion criteria

Exclusion criteria: Nonvital teeth Open apex teeth Pulp inflammation Pulp necrosis Root resorption Periapical diseases The bleeding of the exposed pulp cannot be controled in 10 minutes

Design outcomes

Primary

MeasureTime frame
Hard tissue bridge formation in CBCT 31/12/2024 Computer softwares,pain assessment 31/12/2022 VAS scale

Secondary

MeasureTime frame
Reparative dentin bridge formation in histologic sections 31/12/2025 Hematoxylin-eosin stain/ immunochemistry stain ,Bacteria assessment 31/12/2025 Microscope, Gram staining

Countries

Vietnam

Contacts

Public ContactBui Anh

University of Medicine and Pharmacy at Hochiminh city, Vietnam

buihuynhanh@ump.edu.vn84909094950

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026