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A combined effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) and cathodal transcranial direct current stimulation (tDCS) over non-lesional primary motor cortex on upper limb motor recovery in subacute stroke

A combined effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) and cathodal transcranial direct current stimulation (tDCS) over non-lesional primary motor cortex on upper limb motor recovery in subacute stroke

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20191027002
Enrollment
Unknown
Registered
2019-10-27
Start date
2015-02-13
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. patients with subacute stroke diagnosed with incomplete hemiparesis&#44

Interventions

1. real low&#45
frequency repetitive transcranial magnetic stimulation (rTMS) and cathodal transcranial direct current stimulation (tDCS) over non&#45
lesional primary motor cortex in patients with subacute stroke 2. physical therapy and occupational therapy training,1. sham low&#45
lesional primary motor cortex in patients with subacute stroke 2. physical therapy and occupational therapy training
Experimental Device,Sham Comparator Device
Active rTMS & tDCS,Sham rTMS & tDCS

Sponsors

Faculty of Medicine, Chiang Mai University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
21 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Thai nationality (2) age above 20, and not exceed 80 (3) Have been diagnosed with stroke within 3 months (4) Can follow orders in 2 consecutive steps

Exclusion criteria

Exclusion criteria: (1) A recurrent stroke (2) Other non-cerebrovascular disease; such as, brain tumors, brain injury (3) Unstable medical conditions; such as, uncontrolled arrhythmia, acute coronary syndrome, congestive heart failure, end stage renal disease, pneumonia, urinary tract infection (4) Use a Neurostimulator; such as, Vagal nerve stimulator, deep brain stimulator (5) Use a pacemaker (6) Metal inside the skull or in the ear (7) History of epilepsy (8) Have a seizure within 1 year (9) History of substance abuse (10) Pregnant (11) Has been stimulated with rTMS or tDCS before.

Design outcomes

Primary

MeasureTime frame
Medical Research Council scale of upper extremity (MRC-UE) score,Medical Research Council scale of lower extremity (MRC-LE) score,Brunnstrom stage of arm (BS-ARM) score,Brunnstrom stage of hand (BS-HAND) score,Fugl-Meyer upper extremity motor score (FMA-UE) prior the intervention, immediately after intervention and 1 week after intervention ratio scale,Fugl-Meyer upper extremity motor score (FMA-UE) score,Wolf motor function test - Functional ability (WMFT- FAS) prior the intervention, immediately after intervention and 1 week after intervention ratio scale,Wolf motor function test - Performance time (WMFT-TIME) prior the intervention, immediately after intervention and 1 week after intervention ratio scale—

Secondary

MeasureTime frame
N/A N/A N/A—

Countries

Thailand

Contacts

Public ContactPakorn Wivatvongvana

Faculty of Medicine, Chiang Mai University

pwivatvo@gmail.com053-936322

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026