Allergic rhinitis
Conditions
Interventions
Ginger extract capsule at dose of 250 mg two times a day after meal daily for 42 days
,Loratadine tablet at dose of 10 mg one times a day after morning meal daily for 42 days
Experimental Drug,Active Comparator Drug
Sponsors
Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR)
Faculty of Medicine,
Thammasat University,
Thailand
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.. Patients have history of allergic rhinitis on the basis of “Allergic Rhinitis and its Impact on Asthmaâ€;itching and nasal obstruction, watery nasal discharge, sneezing, congestion 2. Patients have moderate allergic rhinitis diagnosed by doctor with a minimum total nasal symptom score of 5 points 3. Volunteers wish to participate in the research
Exclusion criteria
Exclusion criteria: 1. Patients have ginger allergy. 2. Patients get serious side effects from loratadine. 3. Patients have fever. 4. Patients have respiratory disease such as tuberculosis, nasal polyps. 5. Patients have history of disease: heart disease, kidney disease, liver disease, epilepsy, high blood pressure, severe asthma and gall Stone. 6. Patients have higher than normal value in liver function and renal function. 7. Patients are pregnant or breastfeeding. 8. Immunocompromised patients 9. Patients have taken anti-coagulant, anti-platelet aggregation medications, Macrolides(erythromycin, clarithromycin), Imidazole (ketoconazole, itraconazole, fluconazole), HIV protease inhibitors, Other drugs that inhibit the enzyme CYP450 (cimetidine, metronidazole, zafirlukast, SSRIs) 10. Patients can not stop taking antihistamine or intranasal steroids for 1 week before trial. 11. Communication problems especially listening and interview. 12. The patient cannot be free from the research plan for 14 days. 13. Those who are participating in another research project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Nasal symptom 42 days Total nasal symptom score,Nasal patency 42 days Acoustic rhinometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life 42 days Rhinoconjuctivitis Quality of Life questionnaires (Rcq-36),safety 42 days blood analysis | — |
Countries
Thailand
Contacts
Public ContactArunporn Itharat
Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR)
Outcome results
None listed