Sepsis is a life-threatening condition, and is a common cause of death despite advances in the supportive care of the critically ill. Sepsis, probiotics, gut microbiota
Conditions
Interventions
Boost optimum® feeding via nasogastric tube for 7 days,
initiation and feeding protocol,
according to the primary physician (25-
30 kcal/kg/day) ,Ensure® feeding via nasogastric tube for 7 days,
initiation and feeding protocol according to the primary physician(25-
30 kcal/kg/day)
Experimental Dietary Supplement,Placebo Comparator Dietary Supplement
Boost optimum® diet ,Ensure® diet
Sponsors
Faculty of Medicine, Prince of Songkla University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age > 18 years old Diagnosed of sepsis, severe sepsis and septic shock according to 1992 criteria. Admission to medical wards, a respiratory care unit or a medical intensive care unit less than 48 Intubation and on nasogastric tube. Receive antibiotic less than 48 hours. Able to receive enteral feeding.
Exclusion criteria
Exclusion criteria: Terminally ill patients. Pregnancy. Diarrhea or hematochezia. Short bowel disease. History of allergy to milk or soybean. Contraindication to enteral feeding. Immunocompromised (AIDS, malignant hemopathy, neutrophil count less than 500 per mm3, cytostatic chemotherapy during the past 3 months, before ICU admission)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ,Fecal microbial diversity (Shannon index) 3 days Rectal swabs at day 1 and 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilator-associated pneumonia In-hospital Clinical and laboratory data,Nosocomial diarrhea In-hospital Clinical and laboratory data,Mortality In-hospital and 28 days Clinical data | — |
Countries
Thailand
Contacts
Public ContactVeerapong Vattanavanit
Prince of Songkla University
Outcome results
None listed