To evaluate safety of long-
Conditions
Interventions
Patients with chronic rhinosinusitis with/without nasal polyp who had planned to receive endoscopic sinus surgery with post-
operative budesonide nasal irrigation 0.5mg/day or more.
Treatment
CRS patients with post op budesonide nasal irrigation
Sponsors
ENT department, Chulalongkorn hospital
ENT department,
Chulalongkorn hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with chronic rhinosinusitis with/without nasal polyp who had planned to receive endoscopic sinus surgery with post-operative budesonide nasal irrigation 0.5mg/day or more. 2. Age 18-70 years old
Exclusion criteria
Exclusion criteria: 1. Patients with pituitary disease, adrenal gland disease, or morbid obesity 2. Patients who received systemic glucocorticoids (intravenous, intramuscular, and oral form) during experiment except for the treatment of chronic rhinosinusitis 3. Patients who had pregnancy. 4. Patients who had medications that effect cortisol. 5. Patients who underwent estrogen therapy or received estrogen oral contraceptive pill. 6. Patients who had abnormal serum morning cortisol before nasal irrigation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum morning cortisol level 0,3,6 months Blood test | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactSorranut Thaweboon
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Outcome results
None listed