Analgesic Effect of Addition Intravenous Dexamethasone to Bupivacaine for Ultrasound-guided Thoracic Paravertebral Block in Video-assisted Thoracoscopic Surgery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20191010002

Enrollment

Registered

2019-10-10

Start date

2019-12-20

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesic Efficacy of Intravenous Dexamethasone as an Adjunct to Bupivacaine for Ultrasound-guided Paravertebral Block in Video-assisted Thoracoscopic Surgery Ultrasound-guided thoracic paravertebral block Intravenous dexamethasone Video-assisted thoracoscopic surgery

Interventions

Patients in dexamethasone group (group D) will be received intravenous 8 mg (1.6 mL) of dexamethasone ,Patients in control group (group C) will be received intravenous 1.6 mL of isotonic saline

Active Comparator Drug,Placebo Comparator No treatment

Dexamethasone group,Control group

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Elective video-assisted thoracoscopic surgery for lung surgery American Society of Anesthesiologists Classification 1-3

Exclusion criteria

Exclusion criteria: Body mass index > 35 kg/m2, pre-existing neuropathy (assessed by history and physical examination), history of previous thoracic surgery, significant thoracic kyphoscoliosis, coagulopathy (platelets < 100,000/mL or INR > 1.4), allergy or contraindicated to medications used in study protocol, suspected newly diagnosed diabetes mellitus on the initial screening (preoperative fasting POC glucose > 126 mg/d), uncontrolled diabetes mellitus (HbA1C > 7%), chronic opioid use, chronic systemic corticosteroid use, active infectious condition and refuse to participate

Design outcomes

Primary

Measure	Time frame
Duration of analgesia The first time when patient push IV PCA button The time from the block time to the first analgesic requirement	—

Secondary

Measure	Time frame
Intraoperative hypotension Intraoperative period BP < 90/60 mmHg or MAP < 20% from baseline BP,Intraoperative fentanyl consumption Intraoperative period mcg,Pain score at rest and on movement At 6 hours, 12 hours, 24 hours and 48 hours postoperatively From 0 (no pain at all) to 10 (worst imaginable pain) ,Postoperative morphine consumption 48 hour after the operation mg,Patient satisfaction score At 48 hours postoperatively From 0 (worst) to 10 (best) ,Complications At 48 hours postoperatively Yes or No	—

Measure

Time frame

Intraoperative hypotension Intraoperative period BP < 90/60 mmHg or MAP < 20% from baseline BP,Intraoperative fentanyl consumption Intraoperative period mcg,Pain score at rest and on movement At 6 hours, 12 hours, 24 hours and 48 hours postoperatively From 0 (no pain at all) to 10 (worst imaginable pain) ,Postoperative morphine consumption 48 hour after the operation mg,Patient satisfaction score At 48 hours postoperatively From 0 (worst) to 10 (best) ,Complications At 48 hours postoperatively Yes or No

—

Countries

Thailand

Contacts

Public ContactSivaporn Termpornlert

Department of Anesthesiology, Ramathibodi Hospital, Mahidol University

sorahajime@hotmail.com66815528552

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026