Comparison efficacy of Chlorthalidone and Hydrochlorothiazide for the treatment of systemic hypertension

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20191006002

Enrollment

Registered

2019-10-06

Start date

2019-10-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertensive patients Chlorthalidone Hydrochlorothiazide Efficacy Hypertension

Interventions

Antihypertensive drug,Antihypertensive drug

Experimental Drug,Active Comparator Drug

Chlorthalidone,Hydrochlorothiazide

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Age > 18 years Newly diagnosed or known hypertension (BP > 140/90 mmHg)

Exclusion criteria

Exclusion criteria: Secondary hypertension Curable hypertension History of previous diuretic use ALT > 2X UNL Cr > 1.5 mg/dl SBP > 180/110 mmHg Participants in other study Pregnancy Unable to follow-up History of gout or serum uric acid > 10 mg/dl

Design outcomes

Primary

Measure	Time frame
Decrease in systolic blood pressure, number of patients that achieved blood pressure goal baseline, 6 week, 12 week Automatic blood pressure measurement	—

Secondary

Measure	Time frame
Drug side effect baseline, 6 week, 12 week Blood chemistry measurement, patient's symptom	—

Countries

Thailand

Contacts

Public ContactRungroj Krittayaphong

Faculty of medicine, Siriraj hospital, Mahidol university

rungroj.kri@mahidol.ac.th024197000

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026