Efficacy of Diacerein on ocular surface disease in degenerative arthritis patients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20190930001

Enrollment

Registered

2019-09-30

Start date

2019-10-18

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ocular surface disease Ocular surface disease, dry eye, ocular surface inflammation, diacerein, interleukin-1, interleukin-1 receptor antagonist, osteoarthritis

Interventions

Participant who take Diacerein.

Treatment

Diacerein

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Osteoarthritis with 2.OSDI>13 with 3.Corneal staining score >=3

Exclusion criteria

Exclusion criteria: 1.Allergic to diacerein 2.Use Cyclosporin within 30 days 3.Eyelid problem 4.Change artificial tear while in the study 5.Pregnancy or breast feeding

Design outcomes

Primary

Measure	Time frame
Corneal staining score At the time of enrollment and after 2 months Stain Cornea with Fluorescine, count and score staining at the cornea	—

Secondary

Measure	Time frame
OSDI score At the time of enrollment and after 2 months Ocular Surface Disease Index,Tear Osmolarity At the time of enrollment and after 2 months Use Tearlab to measure tear osmolarity,TBUT At the time of enrollment and after 2 months Stain Cornea with Fluorescine, wait until tear film break, record time that tear break,Schirmer 1 test At the time of enrollment and after 2 months place Schirmer strip at the fornix without anesthesia, wait for 5 min, record tear distance,IL-1Ra, IL-1 alpha, IL-1 beta level in tear At the time of enrollment and after 2 months Extract tear from Schirmer strip and use Bioplex for cytokine measurement	—

Measure

Time frame

OSDI score At the time of enrollment and after 2 months Ocular Surface Disease Index,Tear Osmolarity At the time of enrollment and after 2 months Use Tearlab to measure tear osmolarity,TBUT At the time of enrollment and after 2 months Stain Cornea with Fluorescine, wait until tear film break, record time that tear break,Schirmer 1 test At the time of enrollment and after 2 months place Schirmer strip at the fornix without anesthesia, wait for 5 min, record tear distance,IL-1Ra, IL-1 alpha, IL-1 beta level in tear At the time of enrollment and after 2 months Extract tear from Schirmer strip and use Bioplex for cytokine measurement

—

Countries

Thailand

Contacts

Public ContactNathapon Treewipanon

Department of Ophthalmology, Chulalongkorn university

à¸´book156@gmail.com0896932677

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026