Limbal stem cell deficiency limbal stem cell deficiency (LSCD)
Conditions
Interventions
cultivated oral mucosal epithelial transplantation for limbal stem cell deficiency
Experimental Procedure/Surgery
cultivated oral mucosal epithelial transplantation
Sponsors
National Science and Technology Development Agency
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with unilateral or bilateral limbal stem cell deficiency (LSCD) from chemical or thermal burns, chronic keratitis, multiple corneal surgeries, and prolonged use of eye drops 2. Patients with clinical signs of LSCD at least 180 degrees of the corneal circumference 3. Patients diagnosed with LSCD by impression cytology
Exclusion criteria
Exclusion criteria: 1. Patients aged below 18 years 2. Patients with severe dry eye (Schirmer's test = 0 mm) 3. Patients with uncontrollable glaucoma 4. HIV-infected patients 5. Patients with hepatitis C virus infection 6. Patients with ongoing ocular infection 7. Patients with contraindications of ocular surgery or general anesthesia 8. Patients with pregnancy 9. Patients unable to follow-up 10. Patients with non-compliance, physically or mentally Additional exclusion criteria for allo-SLET patients 1. Patients with contraindications of immunosuppressive agents or sterioids e.g. uncontrollable diabetes mellitus, ongoing systemic infection, hepatic failure, renal failure, etc. 2. Patients allergic to immunosuppressive agents or steroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ocular surface status pre-op, post-op at 1, 3, 6, 9, 12, 15, 18, 21, 24, 27, 30, 33, 36 mo signs of limbal deficiency, impression cytology, and in vivo confocal microscopy | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Contacts
Public ContactPinnita Prabhasawat
Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed