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Relationships between genetic variability and plasma donepezil levels in Thai patients with dementia

Relationships between CYP2D6, genotype, activity score and plasma donepezil levels in Thai patients with dementia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
TCTR
Registry ID
TCTR20190924003
Enrollment
Unknown
Registered
2019-09-24
Start date
2016-12-29
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dementia Dementia Donepezil CYP2D6

Interventions

A cohort of unrelated Thai dementia patients during the maintenance phase of treatment with cholinesterase inhibitor (donepezil) were enrolled from the Dementia Outpatient Clinic&#44
King Chulalongkorn Memorial Hospital&#44
Bangkok&#44
Thailand.
Basic Science
Dementia patient

Sponsors

Faculty of Medicine, Chulalongkorn Unviersity
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 100 Years

Inclusion criteria

Inclusion criteria: Thai dementia patients during the maintenance phase of treatment with cholinesterase inhibitor (donepezil) were enrolled from the Dementia Outpatient Clinic, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Exclusion criteria

Exclusion criteria: Patients who were not treated with donepezil.

Design outcomes

Primary

MeasureTime frame
Relationship of CYP2D6 genotype or phenotypes to plasma donepezil concentration 2 year Univariate and multivariate analysis—

Secondary

MeasureTime frame
CYP2D6 allle frequency in dementia patients 2 year Descriptive statistics—

Contacts

Public ContactPajaree Chariyavilaskul

Faculty of Medicine, Chulalongkorn University

pajaree.l@chula.ac.th+66816134664

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026