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Short duration of antibiotic therapy for treatment of catheter-related bloodstream infection caused by Gram-negative bacteria

Incidence of relapse in catheter-related bloodstream infection caused by Gram-negative bacteria receiving short versus prolonged duration of antibiotic therapy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190914001
Enrollment
Unknown
Registered
2019-09-14
Start date
2016-11-20
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Catheter&#45

Interventions

Antibiotic discontinuation at 7 days after catheter removal,At least 14&#45
day duration of antibiotic therapy
Experimental Drug,No Intervention Drug
Short duration therapy,Prolonged duration therapy

Sponsors

Faculty of Pharmacy, Mahidol University, Thailand
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Hospitalized patients with catheter-related bloodstream infection caused by culture proven Gram-negative bacteria 2. Patients receive appropriate antibiotic treatment

Exclusion criteria

Exclusion criteria: 1. Patients without catheter removal 2. Patients have prosthetic valve or synthetic endovascular graft 3. Patients with neutropenia evaluated on antibiotic discontinuation day 4. Patients with persistent bacteremia, suppurative thrombophlebitis, septic emboli or other metastatic infectious complications such as infective endocarditis, septic arthritis, osteomyelitis, spondylodiscitis and deep-seated abscess evaluated on antibiotic discontinuation day 5. Patients have other indications for antibiotics that make them received antibiotic more than 7 days

Design outcomes

Primary

MeasureTime frame
Relapse at 7 days after antibiotic discontinuation Hemoculture—

Secondary

MeasureTime frame
Death within 30 days after antibiotic discontinuation Case review—

Countries

Thailand

Contacts

Public ContactฺBhitta Surapat

Division of Clinical Pharmacy, Department of Pharmacy Faculty of Medicine, Ramathibodi Hospital, Mah

hopepopotamus@hotmail.com0868006020

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026