sarcopenia hand grip strength BIA CT scan sarcopenia BCAA cirrhosis
Conditions
Interventions
received BCAAs,received placebo
Experimental Drug,Placebo Comparator Drug
BCAA group,placebo group
Sponsors
EA Pharma Co., Ltd.
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: - Age between 18 to 70 years old. - Meet criteria for cirrhosis and sarcopenia as mentioned above - Agree to sign inform consent
Exclusion criteria
Exclusion criteria: - Found hepatocellular carcinoma (HCC) or other malignancy that life expectancy 140/90 mmHg despite optimal medications) o Uncontrolled DM (HbA1C>7.5% despite optimal medications) o Advanced stage CKD (GFR<30 ml/min/1.73m2 ) o Uncontrolled ascites (detectable ascites by physical examination despite optimal diuretics) - Pregnancy or lactation - Refuse to participate the study - MELD score ≥ 20 points
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sarcopenia at baseline and at month 6 Mean change in hand grip strength and percent change in CT Skeletal muscle index | — |
Secondary
| Measure | Time frame |
|---|---|
| percent change in albumin AFP HCC CTP MELD at baseline, month 3,month 6,month 9 blood sample analysis machine | — |
Countries
Thailand
Contacts
Public ContactTeerha Piratvisuth
Songklanagarind hospital
Outcome results
None listed