Pediatric patient age 1 month to 18 years who admit into pediatric wards in King Chulalongkorn Memorial Hospital and receive the PTZ Extended infusion,
Conditions
Interventions
Extended infusion: drip Piperacillin in 4 hours q 8 hour,Bolus infusion: drip Piperacillin in 30 minutes q 8 hour
Active Comparator Procedure/Surgery,Active Comparator Procedure/Surgery
Extended Infusion of Piperacillin in Children,Bolus Infusion of Piperacillin in Children
Sponsors
None listed
Eligibility
Sex/Gender
All
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: Age 1month to 18 years Body weight more than 3 kilograms Paticipants will receive Piperacillin Tazobactam for treatment
Exclusion criteria
Exclusion criteria: Received PTZ within 7 days prior to the day of enrollment Receiving any types of renal replacement therapy RRT or extracorporeal membrane oxygenation ECMO Penicillin allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of plasma piperacillin concentration above MIC at mid-dosing interval and through mid-dosing interval and through high performance liquid chromatography (HPLC) | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of antibiotic escalation 30 days Medical record,30-day overall mortality 30 days Medical record,Length of hospital stay 30 days Medical record | — |
Countries
Thailand
Contacts
Public ContactTatchanapong Chongcharoenyanon
Faculty of medicine, Chulalongkorn university
Outcome results
None listed