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Conditions
Interventions
Controlled arm,Experimental arm
Radiation to all sites of residual tumor
Observe,Consolidative Radiation
Sponsors
Ratchadapisek Sompoch
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - 18 years of age or older - An Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 2 or less. - Lung cancer stage IV disease according to the 8 th edition of the American Joint Committee on Cancer staging system. - Pathologically confirmed NSCLC with EGFR sensitizing mutation (exon 19 deletion or exon 21 L858R mutation) - Had received first-line systemic therapy, either chemotherapy or targeted therapy from King Chulalongkorn Memorial Hospital. - Did not progress during initial first-line systemic treatment. - Synchronous oligometastatic disease (1 to 5 lesions after 4-6 cycles of chemotherapy or 3-4 months of targeted therapy)
Exclusion criteria
Exclusion criteria: - Not meet inclusion criteria. - Patients who needs emergency radiation to the primary tumor or metastatic sites before receiving 1 st line systemic treatment, e.g. symptomatic CNS metastases who are neurologically unstable, spinal cord compression, airway obstruction from tumor. - Patients who have only malignant effusion as a metastatic site after 1 st line systemic treatment. - Females of childbearing or breast feeding. - Pregnancy. - Inadequate bone marrow or organ function as demonstrated by any of the following laboratory values: absolute neutrophil count<1,500/mcl, platelet<100,000/mcl, hemoglobin <8 g/dl. - Complete response to prior systemic treatment to all visible lesions, such that no lesion is amenable to consolidative local radiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival Time to death or progression of disease after randomization Month | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival Time to death after randomization Month,Local control Time to local recurrence after randomization Month,Time to new metastasis lesion Time to develop new metastatic lesion after randoimzation Month,Treatment related toxicities During radiation, 1 month, 3 months, 6 months, 1 year after radiation RTOG toxicities grades | — |
Countries
Thailand
Contacts
Public ContactChonnipa Nantavithya
King Chulalongkorn Memorial Hospital
Outcome results
None listed