Patients who are undergoing surgery with general anesthesia ASA physical status I and II aescin postoperative sore throat incidence
Conditions
Interventions
placebo tablet that resembles the experimental one,Aescin extract is commercially sold in tablets with Trade name Reparil. The patient in experimental group will take Reparil 2 tabs within 2 hours bef
Placebo Comparator Drug,Experimental Drug
placebo,Aescin
Sponsors
HRH Princess Maha Chakri Sirindhorn Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age > 18-64 years. American Society of Anesthesiologists physical status I-II Elective gynecologic surgery, abdominal surgery, breast surgery, orthopedic surgery Supine surgical position and neutral neck position Operation time more than 1 hour and less than 6 hours
Exclusion criteria
Exclusion criteria: Known hypersensitivity to aescin and any drugs in this study Glucose, galactose, fructose intolerance Renal insufficiency/renal failure or kidney diseases Pregnancy Preoperative sore throat History of upper respiratory tract illness Pre-existing pulmonary disease History of psychiatric disorders History of difficult intubation/suspected difficult airway Excessive external laryngeal manipulation Insert any equipment to oral cavity ex. Panendoscopy, ERCP, EGD, dilate esophagus, NG or OG insertion, nasal temperature probe Patients who are already intubated before general anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative sore throat up to 24 hours post operative incidence comparison | — |
Secondary
| Measure | Time frame |
|---|---|
| severity of postoperative sore throat up to 24 hours mean comparison,speed of recovery from postop sore throat within 24 hours postop log-rank test | — |
Countries
Thailand
Contacts
Public ContactChaiyapruk Kusumaphanyo
Srinakharinwirot university
Outcome results
None listed