Thoracic-
Conditions
Interventions
Loading dose: tranexamic acid 1 g intravenous 30 minutes before operation
Intervention: tranexamic acid 1 g(20 ml) with Absorbable gelatin sponges on surgical site before wound closure ,Loading dose:
Experimental Drug,Placebo Comparator Other
Sponsors
Department of Orthopedics, Chiangmai University
Research Administration Sections,
Faculty of medicine,
Chiangmai University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: -Patients undergoing T-L level spinal tumor decompression and instrumentation -Aged over 18 years
Exclusion criteria
Exclusion criteria: -Allergic to tranexamic acid -Coagulopathy or Bleeding tendency -History of thromboembolic events -Serum creatinine level > 2 mg/dL - Pregnancy or breast feeding - ASA class IV
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative blood loss Since operation finish till postoperative day 3 PBL = Total blood loss (patient's blood volume (PBV) × (Hctpre - Hctpost) / Hctave) - Intraop | — |
Secondary
| Measure | Time frame |
|---|---|
| Complication 3 days post operative hematoma, infection, wound dehiscence,Deep vein thrombosis, Pulmonary embolism, Myocardial infarctio,Transfusion of blood component within 3 day post-operative 3 days post operative Unit of blood component | — |
Countries
Thailand
Contacts
Public ContactRonnakrit Maethungkul
CHIANGMAI UNIVERSITY
Outcome results
None listed