Healthy Thai subjects aged between 30-
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy male or female aged between 30-65 years old 2. All skin types (normal, dry, oily or mixed skins) 3. Having Fitzpatrick skin type III - V 4. Having clear visible wrinkle at eye corner (crow’s feet) 5. Having consent in the study after be informed objective, methodology, possible risk and result, and be able to follow the study protocol 6. Be able to read, communicate and write Thai language
Exclusion criteria
Exclusion criteria: 1. Having history of eczema, psoriasis within 6 months before enroll the study 2. Having history of using steroid, antibiotic, NSAIDs and antihistamine within 3 days before enroll the study 3. Having history of topical medicine uses on the face within 3 weeks before enroll the study 4. Having underlying diseases and taking continuous medicines 5. Having history of major operation within 1 year 6. Having history of skin cancer within 1 year 7. Having pregnancy or lactation 8. Being or having experience in participating other clinic
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin lightening effect week 0, 2, 4, 6, 8 Mexameter® and Chromameter ,Skin roughness and wrinkles week 0, 2, 4, 6, 8 PRIMOSlite,Facial photograph of the crow’s feet area week 0, 2, 4, 6, 8 Canon EOS Rebel T5i 700D,Self-assessment after week 8 Questionnaire form | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Cosmetics and natural products research center, Faculty of Pharmaceutical Sciences, NU