Wound healing of tooth extraction socket Vitamin C Local administration Systemic administration Tooth extraction Wound healing
Conditions
Interventions
The patients will receive vitamin C 100 mg,
2 tablets/ time and 3 times/ day for 14 days,The patients will hold the first vitamin C tablet over the tongue until it dissolves completely. Then,
the second vitamin C tablet will be hold over the tongue. Vitamin C tablet will have no direct contact to extracted wound. Chewing the vitamin C tablets must be avoided.The patients will receive vitam
each patient will be randomly selected which side of the tooth will be extracted and which intervention will be prescribed. After 21 days,
tooth on another side will be extracted and each patient will receive the other intervention for 14 days.
Swallowing vitamin C 200 mg.,Keeping vitamin C in the mouth 200 mg.,Compare between swallowing vitamin C 200 mg. and keeping vitamin C in the mouth 200 mg.
Sponsors
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
15 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Patients who have bilaterally symmetrical non-infected premolars needed for extraction such as extraction for orthodontic treatment 2. Age between 15 to 35 years 3. Patients who have American Society of Anesthesiologist (ASA) class I or II 4. No antibiotic usage 5. Simple/ atraumatic extraction
Exclusion criteria
Exclusion criteria: 1. Infection is found at site of extraction 2. Smokers or alcoholics 3. On drug therapy which may affect wound healing such as glucocorticoid steroids and non-steroidal anti-inflammatory drugs 4. Pregnant woman, lactating women and patients who take estrogen-containing contraceptive drugs 5. Patients who have blood disorders like thalassemia, G6PD deficiency, sickle cell disease and hemochromatosis. 6. Psychiatric patients 7. Patients who cannot participate with the study and post-operative follow-up 8. Other vitamin consumptions 9. Patients who cannot take vitamin C at least 2 times/ day and miss to take vitamin C more than 4 times in the period of 14 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| soft tissue healing 7 days post-operation and 21 days post-operation The modified of Landry index,size of the sockets Immediately after extraction, 7 days post-operation and 21 days post-operation caliper and periodontal probe ,bone healing Immediately after extraction and 21 days post-operation computer software (ImageJ) ,bone healing Immediately after extraction and 21 days post-operation computer software (ImageJ) | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pain Postoperative day 1,2,3 visual analogue scale | — |
Countries
Thailand
Contacts
Public ContactPaksinee Kamolratanakul
Department of oral and maxillofacial surgery
Outcome results
None listed