Modulation of Cytokines Expression induced by Lactobacillus spp. as a Potential Therapeutic Strategy to Suppress Inflammation Process of Knee Osteoarthritis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20190823002

Enrollment

Registered

2019-08-23

Start date

2019-07-26

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis osteoarthritis bacterial DNA Inflammatory cytokines

Interventions

cells are treated with bacterial media and cytokines after treatment will be measured.

Basic Science

Treatment with bacterial media

Eligibility

Sex/Gender

All

Age

40 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients with knee osteoarthritis by criteria of diagnosis according to American College of Rheumatology who has undergone total knee arthoplasty at King Chulalongkorn Memorial Hospital.

Exclusion criteria

Exclusion criteria: - Patients with other coexisting arthropathies such as gout, pseudogout, rheumatoid arthritis, SLE, hemochromatosi - Patients with other coexisting arthritic conditions such as previous knee injury, and previous joint infection - Patients with other coexisting underlying disease such as cancer, systemic inflammatory conditions, and autoimmune disorders

Design outcomes

Primary

Measure	Time frame
Cytokine levels after treatment at 6,12,24,72 hourss after end of the intervention Cytometric bead array	—

Secondary

Measure	Time frame
Cytokine levels before treatment at 6,12,24,72 hourss after end of the intervention Cytometric bead array	—

Countries

Thailand

Contacts

Public ContactPalapun Waitayangkoon

Faculty of Medicine, Chulalongkorn University

palapun@gmail.com+66863658564

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026