None listed
Conditions
Interventions
Ondansetron administered every 8 hours - standard arm,Ondansetron administered as a single dose daily - experimental arm
Active Comparator Drug,Experimental Drug
Ondansetron divided dose every 8 hours,Ondansetron single daily dose
Sponsors
Phramongkutklao Hospital and College of Medicine
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: - Age less than 18 years old - Diagnosed with cancers and required chemotherapy - Having indication to receive ondansetron to control nausea/vomiting symptoms - Providing informed assent with parental permission to participate to this study
Exclusion criteria
Exclusion criteria: - Having kidney or liver disease - Allergy to ondansetron - History of QTc prolongation - Receiving drugs in a group of serotonergic agents - Pregnancy - Receiving radiation therapy to chest and abdomen - Having other causes for nausea/vomiting such as gut obstruction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numbers of vomiting after first dose of ondansetron to 24 hours after the last dose of ondansetron Frequency and percentage | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea symptom after first dose of ondansetron to 24 hours after the last dose of ondansetron Visual analog scale (1-10),Side effects of ondansetron after first dose of ondansetron to 24 hours after the last dose of ondansetron Frequency and percentage | — |
Countries
Thailand
Contacts
Public ContactPiya Rujkijyanont
Phramongkutklao Hospital and College of Medicine
Outcome results
None listed