mild cognitive impairment (MCI) mild cognitive impairment early detection dementia screening brain imaging cognitive stress perfusion SPECT
Conditions
Interventions
LASSI-
L is a neuropsychological test use for cognitive stress to stimulate brain perfusion in SPECT study. It will be applied to all subjects.
Experimental Behavioral
Sponsors
Ratchadapiseksompotch Grant, Chulalongkorn University
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: - Age 55 - 85 years - No known history of uncontrolled psychiatric disease - Stable controllable dementia without choline esterase inhibitor adjustment in the past 3 months - Thai nationality
Exclusion criteria
Exclusion criteria: - Diseases which affect this study eg.chronic kidney disease (GFR=7mg% ), all types of cancer - Who cannot perform CT or MRI of the brain - Those who have dementia etiology from other causes eg. depression, cerebrovascular disease, etc. - Patients with neurological disease that affects cognition eg. epilepsy, parkinson disease etc. - Those who cannot read/write/speak Thai language. - Those who have MRI finding of frank cerebrovascular disease - Those who have abnormal lab tests: CBC, Bun, Cr, Electrolytes, LFT, metabolic blood test (Thyroid Function Test, folate, B12, lipid profile, FBS, HbA1c), inflammation/infection blood tests (Syphilis, HIV, ESR) - Mild dementia patients with abnormal special blood test (autoimmune/paraneoplastic panel, antineuronal IgG, anti-TPO, anti-thyroglobulin)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's dementia at 3 years after detection of mild cognitive impairment & SPECT Brain perfusion SPECT | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE and MoCA score at 3 years MMSE and MoCA neurophyschological tests | — |
Countries
Thailand
Contacts
Public ContactSupatporn Tepmongkol
Chualongkorn University
Outcome results
None listed