Obstructive sleep apnea Obstructive sleep apnea Cognitive impairment Memory Executive function Elderly Magnetic resonance imaging
Conditions
Interventions
Screening
Obstructive sleep apnea
Sponsors
Chulalongkorn University
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed with moderate to severe OSA by a split-night laboratory polysomnography (apnea hypopnea index ≥ 15)
Exclusion criteria
Exclusion criteria: 1.Severe systemic diseases : cirrhosis (Child-Pugh score B or C), chronic kidney disease stage 3 or more, pulmonary disease with chronic hypoxia or hypercarbia, heart failure NYHA II or more 2.Psychiatric illness 3.Neurological diseases : brain tumor, stroke, epilepsy, coma, history loss of consciousness of more than 30 mins after head trauma, encephalitis 4.Use of psychotropic medications 5.Alcohol or illicit drug abuse 6.Prior therapy for OSA 7.Sleep disorders other than OSA including central sleep apnea, insomnia, REM behavioral disorder, restless leg syndrome, periodic limb movement disorder, narcolepsy 8.Thai Mental State Examination score < 24 9.Inability to complete neuropsychological assessments or not fluent in Thai 10.Contraindications for MRI: presence of cardiac pacemaker or defibrillator, presence of metallic implants, claustrophobia, or uncomfortable or unable to lie down still for the MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation of oxygen desaturation index and score from D-KEFS Tower Test Once after diagnosed with OSA D-KEFS Tower Test | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of oxygen desaturation index and composite measurement of executive function tests Once after diagnosed with OSA Battery of executive function tests,Correlation of oxygen desaturation index and composite measurement of memory function tests Once after diagnosed with OSA Battery of memory function tests,Correlation of oxygen desaturation index and composite measurement of attention function tests Once after diagnosed with OSA Battery of attention function tests,Correlation of oxygen desaturation index and composite measurement of processing speed tests Once after diagnosed with OSA Battery of processing speed tests,Correlation of oxygen desaturation index and brain atrophy in prefrontal area Once after diagnosed with OSA Cortical thickness measurement from magnetic resonance imaging of the brain at prefrontal cortex,Correlation of oxygen desaturation index and axonal integrity of frontal lobe Once after diagnosed with OSA fractional anisotropy from diffusion tensor imaging of frontal lobe,Correlation of oxygen desaturation index and function of the prefrontal cortex Once after diagnosed with OSA resting state functional connectivity from functional magnetic resonance imaging of prefrontal corte | — |
Countries
Thailand
Contacts
Public ContactAnthipa Chokesuwattanaskul
Chulalongkorn University
Outcome results
None listed