Female infertile patients In vitro fertilization Combined oral contraceptive pills Corpus luteal cyst Oocyte retrieval
Conditions
Interventions
Patients will receive combined oral contraceptive pills containing 0.15 mg desogestrel and 0.02 mg ethinyl estradiol per pill under Mercilon 28 trademark. Patients have to take this product 1 pill a d
up appointment for 2 weeks,Patients will be appointed the follow-
up 2 weeks after the oocyte retrieval without taking combine oral contraceptive pills (normal procedure)
Experimental Drug,Placebo Comparator No treatment
Combined oral contraceptive pills,Expectant management
Sponsors
Mahidol university
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Female patients at Infertility Unit who have indications for in vitro fertilization. 2. IVF using embryo cryopreservation according to the opinion of the obstetrician or have indications such as - Have more than 20 oocytes. - Endometrium has an inappropriate condition for embryo transfer. - Genetic diagnosis is needed before embryo transfer 3. Women aged 18-45 years. 4. Those who volunteered to participate in research projects.
Exclusion criteria
Exclusion criteria: 1. Contraindications of combined oral contraceptive pills include: a. Women with history of abnormalities in the circulatory system especially the abnormalities related to thrombosis, deep vein thrombosis, pulmonary embolism, coronary heart disease or at other parts of the body. b. Women with history of stroke. c. Symptoms that are suspected to be myocardial infarction or cerebrovascular disease. d. Migraine with symptoms such as vision disorders, aphasia and motor weakness. e. Diabetes with vascular complications. f. Pancreatitis related to high blood cholesterol. g. Jaundice or severe liver disease h. Cancer that may be stimulated by sex hormones such as breast cancer or genital organ cancer. i. Liver tumor both mild and severe types. j. Undiagnosed abnormal vaginal bleeding k. Allergic to ethinyl estradiol or desogestrel l. Smoker over the age of 35. 2. Ovarian cysts occur before the IVF process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of corpus luteal cyst 2 and 4 weeks after oocyte retrieval Transvaginal ultrasonography and measure size of corpus luteal cyst | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration from oocyte retrieval to endometrial preparation after date of endometrial preparation Date calculation,Duration from oocyte retrieval to transfer the embryo. after date of oocyte retrieval Date calculation | — |
Countries
Thailand
Contacts
Public ContactPavarit Humart
Faculty of Medicine Siriraj Hospital, Mahidol university
Outcome results
None listed