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Comparison of the effectiveness between 5% Eutectic mixture of local anesthesia cream, Vapocoolant spray (Ethyl chloride spray) and placebo applying on the skin before intravenous cannulation for decreasing pain.

Comparison of the effectiveness between 5% Eutectic mixture of local anesthesia cream, Vapocoolant spray (Ethyl chloride spray) and placebo applying on the skin before intravenous cannulation for decreasing pain.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190722004
Enrollment
186
Registered
2019-07-22
Start date
2019-02-20
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

All patient health condition and ASA 1&#45

Interventions

Administer the EMLA analgesic cream method&#44
using a 2 mL syringe&#44
0.5 gram of the EMLA cream was applied to the forearm 60 minutes and mineral spray (placebo) from a distance of 4 inch. for 5 seconds and allow 10 seconds to mimic the absorption of anesthetic. The
the spray was administered from a distance of 4 inch&#44
application time of the spray was limited to 5 seconds and allow 10 seconds to the absorption&#44
achieve skin blanching. Our cannulation attempt occurred within 60 seconds after application because vapocoolant spray have a brief duration of action (30&#45
60 seconds) after application which time&#44
nurse perform intravenous cannulation within 60 seconds after process and cleans with alcohol on the skin following the standard procedure for intravenous cannulation.,Administer placebo (mineral spra
application time of the spray was limited to 5 seconds and allow 10 seconds to mimic the absorption of anesthetic. The nurse perform intravenous cannulation within 60 seconds after process and cleans
Experimental Drug,Experimental Drug,Placebo Comparator Drug
group A : 5% EMLA cream , group B : Vapocoolant spray (Ethyl chloride spray), group C : Placebo

Sponsors

Faculty of Medicine Siriraj Hospital, Mahidol University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1.Outpatients who need to be given intravenous fluids for anesthesia under anesthesia. 2.Patients are male or female. 3.>18 year old

Exclusion criteria

Exclusion criteria: 1.Inflammation or skin ulcers within the cannulation area. 2.Known case of hypersensitivity to local anesthetic. 3.Patients with communication difficulties. 4.Patients with impair sensory function of hand. 5.Known case of atopic dermatitis.

Design outcomes

Primary

MeasureTime frame
Pain score While skin is cannulated numeric rating scale—

Secondary

MeasureTime frame
Skin cannulation difficulty score after intravenous cannulation 5 minutes numeric rating scale,patient satisfaction score after intravenous cannulation 5 minutes numeric rating scale—

Countries

Thailand

Contacts

Public ContactWilaiporn Supan

Siriraj Hospital

aea.ns@hotmail.com0874774929

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026