Severe pain at intravenous injection site during induction with Propofol in the patients who undergoing general anesthesia Ondansetron,
Conditions
Interventions
Ondansetron (Injection) 8 mg [clear solution,
4mL] IV before induction with propofol for 1 minute,Lidocaine (non-
preservative) 40 mg [clear solution,
4 mL] IV before induction with propofol for 1 minute,Normal saline [clear solution,
4 mL] IV before induction with propofol for 1 minute
O group,L group,C group
Sponsors
Faculty of Medicine, Prince of Songkla university
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - the American Society Anesthesiologists physical status I–III - aged between 18-65 year-old - underwent elective surgeries under general anesthesia - having an IV catheter no. 20 at a hand dorsum - weight more than 50 kg
Exclusion criteria
Exclusion criteria: - had difficulty in communicating - were allergic to ondansetron or propofol or lidocaine - were allergic to egg or soybean - were using Apomorphine, Dronedarone, Monoamine oxidase inhibitor and serotonergic drugs - Arrhythmia: Prolong QT, second and third degree AV block - Chronic pain - Thrombophlebitis or peripheral neuropathy - Pregnancy or during lactation - rapid sequence intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain incidence [ Verbal numerical rating scale at least 1] after injected propofol for 30 seconds asking from the patient | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea and vomitting incidence evaluate at post anesthetic care unit observe and record | — |
Countries
Thailand
Contacts
Public ContactWirat Wasinwong
Anesthesiology department, Faculty of medicine
Outcome results
None listed