Age more than 18 years HIV infection Diagnosis of cryptococcal meningoencephalitis cryptococcal meningoencephalitis HIV antifungal induction treatment flucytosine amphotericin B
Conditions
Interventions
Take amphotericin B and flucytosine for induction therapy for one week.,Take amphotericin B and flucytosine for induction therapy for two week.
Active Comparator Drug,Active Comparator Drug
week combination amphotericin B and flucytosine for induction therapy ,two-
week combination amphotericin B and flucytosine for induction therapy
Sponsors
Faculty of Medicine Siriraj Hospital
Faculty of Medicine Siriraj Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. HIV-infected patients, 18 years of age or older, 2. Admitted at Siriraj Hospital and another 11 hospitals 3. Definite diagnosis of cryptococcal meningitis
Exclusion criteria
Exclusion criteria: 1. Allergic to amphotericin B or flucytosine 2. Receive amphotericin B or flucytosine more than 72 hours 3. Women who were pregnant or during breast feeding 4. Other fungal infection which treatment by amphotericin B
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality rate 4 weeks Number of population | — |
Secondary
| Measure | Time frame |
|---|---|
| Fungal clearance 14 days Culture,Adverse effect of treatment 14 days Laboratory test,Recurrence rate 90 days Presentation of recurrent Infection | — |
Countries
Thailand
Contacts
Public ContactMethee Chayakulkeeree
Faculty of Medicine Siriraj Hospital
Outcome results
None listed