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The comparison between ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets and non-hormonal long-lasting vaginal moisturizer on the treatment of genitourinary syndrome of menopause: A randomized control trial.

The comparison between ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets and non-hormonal long-lasting vaginal moisturizer on the treatment of genitourinary syndrome of menopause: A randomized control trial.

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190711002
Enrollment
86
Registered
2019-07-11
Start date
2019-07-03
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genitourinary symptom of menopause Genitourinary symptom of menopause

Interventions

2 phases of treatment 1 : Using Ultra&#45
low&#45
dose estriol and Lactobacillus acidophilus vaginal tablets everyday for 12 days 2 : Using Ultra&#45
dose estriol and Lactobacillus acidophilus vaginal tablets 2 times a week for 8 weeks ,2 phases of treatment 1 : Using Non&#45
hormonal long&#45
lasting vaginal moisturizer everyday for 12 days 2 : Using Non&#45
lasting vaginal moisturizer 2 times a week for 8 weeks
Active Comparator Drug,Active Comparator Drug
Ultra&#45
dose estriol and Lactobacillus acidophilus vaginal tablets,Non&#45
lasting vaginal moisturizer

Sponsors

RESEARCH PROMOTION COMMITTEE, FACULTY OF MEDICINE, CHIANG MAI UNIVERSITY
Lead Sponsor
RESEARCH PROMOTION COMMITTEE&#44
Collaborator
FACULTY OF MEDICINE&#44
Collaborator
CHIANG MAI UNIVERSITY
Collaborator

Eligibility

Sex/Gender
Female
Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age >= 40 Menopause ( Last menstrual period more than 12 months) Have had GSM symptom in the past 30 days Understand Thai language

Exclusion criteria

Exclusion criteria: Vaginal infection Have been using vaginal hormone or moisturizer in the past 30 days Estrogen sensitive cancer Undiagnosed vaginal bleeding Allergic to intervention drug/moisturizer Refuse to undergo vaginal exam or virginity

Design outcomes

Primary

MeasureTime frame
Most bothersome symptom 10 weeks Questionaires—

Secondary

MeasureTime frame
VMI, VMV, Vaginal pH,improvement of GSM symptom 10 weeks Questionaires, Vaginal cytology , Vaginal pH—

Contacts

Public ContactSiriparadee Dilokwatana

Chiangmai university

deedy_siri@hotmail.com0992422626

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026