FindTrial
Sign In

Effects of genetic polymorphism of CYP3A5 and UGT1A9 in brain-death donor and liver transplant recipients on pharmacokinetic profiles of tacrolimus and mycophenolate at steady state post-transplantation

Effects of genetic polymorphism of CYP3A5 and UGT1A9 in brain-death donor and liver transplant recipients on pharmacokinetic profiles of tacrolimus and mycophenolate at steady state post-transplantation

Status
Recruiting
Phases
Phase 2
Study type
Observational
Source
TCTR
Registry ID
TCTR20190707002
Enrollment
Unknown
Registered
2019-07-07
Start date
2019-05-31
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thai liver transplant patients (cadaveric liver transplant) Thai liver transplant patients (cadaveric liver transplant)&#44

Interventions

Thai liver transplant patients (cadaveric liver transplant)
Health Services Research

Sponsors

Rachadapisek Sompote Fund.
Lead Sponsor
Ratchadapiseksompotch fund
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Thai liver transplant patients (cadaveric liver transplant) Aged 18 years or older

Exclusion criteria

Exclusion criteria: Thai liver transplant patients (Living liver transplant)

Design outcomes

Primary

MeasureTime frame
genetic polymorphisms and enzymatic activity of CYP3A5 and UGT1A9 0, 1, 2, 4, 6, 9, 12, 24 hrs Buffy coat and Liver Biopsy of CLT donor and recipient ,Effect of CYP3A5 and UGT1A9 polymorphisms on Tacrolimus and mycophenolate levels 0, 1, 2, 4, 6, 9, 12, 24 hrs plasma/ measure by LC-MS/MS—

Secondary

MeasureTime frame
effect of the CYP3A5 variants on acute rejection within 6 months after liver transplant 0, 1, 2, 4, 6, 9, 12, 24 hrs Buffy coat and Liver Biopsy of recipient—

Countries

Thailand

Contacts

Public ContactAthaya Vorasittha

Faculty of medicine,

athayav@gmail.com0816681053

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026