vascular patients postoperative delirium,
Conditions
Interventions
The placebo arm a distilled water 0.5 ml,The risperidone arm a risperidone oral solution 0.5 mg (0.5 mL)
Placebo,risperidone oral solution
Sponsors
Faculty of Medicine Siriraj Hospital, Mahidol University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. patients aged > 60 years 2. undergoing elective vascular surgery 3. operative time > 2 hours.
Exclusion criteria
Exclusion criteria: 1. patients with cognitive impairment (a Thai Mental State Examination score < 24) 2. evidence of alcohol abuse 3. alcohol ingestion occurring in the 14-day period preceding the surgery 4. preoperative delirium (shown by a positive result with the Confusion Assessment Method for the Intensive Care Unit, CAM-ICU) 5. severely impaired renal function (demonstrated by a creatinine clearance < 30 mL/min/1.72 m2) 6. hepatic impairment (a Child Pugh score ≥ 10) 7. allergy to risperidone 8. neuroleptic malignant syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| delirium Admitted to an SICU for a period that was expected to be longer than 24 hour The CAM−ICU score | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Public ContactOrawan Pongraweewan
Faculty of Medicine Siriraj Hospital, Mahidol University
Outcome results
None listed