Efficacy of Local Infiltration Analgesia containing bupivacaine and different doses of Ketorolacin hip arthroplasty; A three-arm randomized trial

Efficacy of Local Infiltration Analgesia containing bupivacaine and different doses of Ketorolacin hip arthroplasty. A three-arm randomized trial

Status

Unknown

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20190627003

Enrollment

Registered

2019-06-27

Start date

2020-01-07

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

1. Does local infiltration analgesia containing Bupivacaine plus ketorolac have more efficacy than Bupivacaine alone in post-operative THA pain control? 2.Does local infiltration analgesia containi local infiltration analgesia, hip arthroplasty, ketorolac

Interventions

Bupivacaine only,Bupivacaine plus 30 mg of ketorolac,Bupivacaine plus 60 mg of ketorolac

Active Comparator Drug,Experimental Drug,Experimental Drug

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Inclusion criteria

Inclusion criteria: Adult aged 20-75 years indicated for unilateral total hip arthroplasty ASA class I or II

Exclusion criteria

Exclusion criteria: o Severe hip deformities or required extensive soft tissue release: - Hip deformities > 30oin any planes - Limb shortening correction > 3 centimeters o Contraindicated to spinal anesthesia or failed to complete spinal anesthesia o Renal function impairment; GFR <50 mL/min o High risk for cardiovascular thrombotic event; eg, history of myocardial infarction, thrombotic stroke o History of peptic ulcer or gastrointestinal(GI) bleeding o History of long-term (>1 month) use of daily opioid medication with an oral morphine equivalent (OME) of >5 mg/day o History of short-term (<1 month) use of daily opioid medication (average OME of >30 mg/day) o History of allergy of bupivacaine, ketorolac, morphine o Unable to provide consent, pain information and cognitive impairment o Intraoperative fractures of both femur and acetabulum

Design outcomes

Primary

Measure	Time frame
Opioid consumption 5 timepoints postoperation milligrams of opioid	—

Secondary

Measure	Time frame
Pain 5 timepoints postoperation Visual analoque scale	—

Countries

Thailand

Contacts

Public ContactRit Apinyankul

Khon Kaen University

ritap@kku.ac.th0850031988

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026