healthy MSM/TG adolescents aged between 15-
Conditions
Interventions
participant will recieved TDF/FTC plus oskept(combination of vitamin D + Calcium),participant will recieved TDF/FTC alone
Experimental Drug,No Intervention No treatment
PrEP + cal/D,PrEP alone
Sponsors
Faculty of Medicine, Chulalongkorn University
Eligibility
Sex/Gender
Male
Age
15 Years to 24 Years
Inclusion criteria
Inclusion criteria: -MSM/TGW -At risk population of HIV infection (at least 1 as follow) Multiple partner (> 1 partner during past 6 months) Condomless sex Serodiscordant couple -age 15-24 years -Desired to received PrEP -anti-HIV: negative
Exclusion criteria
Exclusion criteria: -Acute retroviral syndrome -History of bone fracture -Received Ca > 1,000 mg/day within 6 months before enrollment -Received vitaminD > 400 IU/day within 6 months before enrollment -History of growth hormone def./growth hormone used -History of endocrinopathy including primary hyperparathyroidism, hypoparathyroidism, cushing syndrome -Abnormal renal function test (Cr clearance < 60 ml/min/1.73m2) -History of steroid used in past 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effect of vitamin D and calcium supplement on bone mass density 6 months %BMD change | — |
Secondary
| Measure | Time frame |
|---|---|
| effect of TDF/FTC on bone mass density 6 months %BMD change | — |
Countries
Thailand
Contacts
Public Contactkrittaporn pornpaisalsakul
Center of Excellent for Pediatric Infectious Diseases and Vaccines
Outcome results
None listed