A randomized controlled trial of colistin combined with sulbactam: 9 g per day versus 12 g per day in the treatment of extensively drug-resistant resistant Acinetobacter baumannii pneumonia

Clinical outcome in treatment of MDR A.baumannii pneumonia treated with colistin combined with high dose sulbactam : A randomized control trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20190623002

Enrollment

138

Registered

2019-06-23

Start date

2019-09-28

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extensively drug resistance Acinetobacter baumannii pneumonia XDR A. baumannii, colistin, high dose sulbactam

Interventions

Give colistin combined with sulbactam 9-g/d ,Give colistin combined with sulbactam 12-g/d

Experimental Drug,Experimental Drug

Colistin combined with sulbactam 9-g/d,Colistin combined with sulbactam 12-g/d

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: -A. baumannii XDR pneumonia patients -Age 18 or over 18 years old

Exclusion criteria

Exclusion criteria: -Sputum culture shows mixed organisms -Concurrent or coinfection with other organs -Not received colistin for empirical treatment -Receive colistin >6 calendar days before date of collected sputum -Allergy to colistin or sulbactam -Previous participated in this trial within 14 days -Pregnancy

Design outcomes

Primary

Measure	Time frame
mortality 7 and 28 days mortality rate	—

Secondary

Measure	Time frame
ICU day, ventilator day, adverse event until discharge from ICU, off mechanical ventilator, complete treatment length of ICU stay or mechanical ventilator use, adverse drug events,Factor associated mortality 28 days mortality	—

Countries

Thailand

Contacts

Public ContactChutchawan Ungthammakhun

Phramongklao hospital

rebornhue@gmail.com0969659535

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026