Osteoarthritis patient with acute knee pain. OA,
Conditions
Interventions
Oil extract from Curcuma longa,
Carum carvi,
Myristica fragrans,
Delphinium brunonianum,
Cautleya spicata and Sesamum indicum and patient will be advice to massage with oil and diclofenac gel over anterior and exterior part of knee for three times a day (morning,
afternon & evening for 20 minutes) continues for 7 days from the baseline and applicable for the control and placebo group to follow the same procedure as mentioned., Topical nonsteroidal anti-
inflammatory drugs (NSAIDs) can be alternative treatment to oral pain killers that can relieve symdromatic knee OA pain. The efficacy of topical diclofenac sodium 1% gel (DSG) for symptomatic knee OA
12 weeks of topical DSG showed significantly larger scale of reductions in WOMAC pain (52.6% vs 43.1%
p=0.008) and physical function (49.7% vs 39.4%
P = 0.004) versus vehicle and provided significant improvements in most secondary endpoints (H. S B Basaf et al 2010).
Placebo Comparator Drug,Active Comparator Drug
rTsabyugs,Diclofenac gel
Sponsors
Thammasat University
Thammasat University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: a) Both male and female, age group between 45-75years old b) Body mass index (BMI) < 25 kg/m2 c) The symptoms of OA must have mild to moderate according to the index of severity for OA of the knee. d) Participants with minimum visual analog scale (VAS) score 4-6 e) Good communication and cooperation. f) Participants should not under go any medication before 2 weeks of enrollment in the research. g) Participants oriented to the risks and benefits of the research and willing to sign the consent form.
Exclusion criteria
Exclusion criteria: a) Participants using any topical application during investigation. b) Patient undergone lower extremity surgery in the past 6 months. c) Conditions of erythema, edema and with open wound on the knee. d) Women with pregnancy or breast feeding. e) Participants having allergic to herbs such as; Ccurcuma longa, Myristica fragrans, Carum curvi, Delphnium brununium, Catleya spicata and Plai. f) If the subject plan to admit for surgery or move to other places during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| efficacy of oil in knee pain patients 2 months Knee injury and osteoarthritis outcome scores | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life 2 months , Visual Analog Scale, Knee range of Motion, Quality of life | — |
Countries
Thailand
Contacts
Public ContactDorji Nidup
Thammasat University
Outcome results
None listed