Healthy Asian female subjects aged between 30-
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy female age 30-60 years 2. Having clear visible wrinkle at eye corner and forehead 3.No smoking, alcoholic and drug addiction 4. No history of allergy problem to commercially available anti-wrinkle products 5. Be able to follow the study protocol 6. Written consent of the volunteer 7. Do not take the food supplement of beverage affecting skin nourishing in last month ago 8. Non history in blood, liver and renal diseases 9. Non history in sea food allergy
Exclusion criteria
Exclusion criteria: 1. History of skin hyper allergy 2. History of skin eczema, psoriasis within 6 months before study 3. History of using steriod, antibiotic and antihistamine within 3 days before study 4. History of using topical medicine on the face within 3 weeks before study 5. Having congenital disease 6. History of major operation and skin cancer in last year 7. Having scar on the evaluation area 8. Pregnancy and lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skin Elasticity Day 1, 6, 15, 29 Cutometer,Skin Moisture Day 1, 6, 15, 29 Corneometer,Skin Barrier Function Day 1, 6, 15, 29 Tewameter,Adverse event After use product Evaluated by dermatologist | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Cosmetics and natural products research center, Faculty of Pharmaceutical Sciences, NU