Healthy Thai female subjects aged between 25-
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: - Aged 25-50 years old with Relative Melanin Value (RMV) range 20-120 and/or melasma area and severity index at least 10 - Be able to follow the study protocol - Written consent of the volunteer
Exclusion criteria
Exclusion criteria: 1. History of eczema or psoriasis within 6 months 2. History of herbes 3. Incident of facial warts, wounds or scars 4. Medical or cosmetic treatment with steroids, antibiotics, NSAIDs, anti-histamine, azelaic acid, kojic acid, hydroquinone, chemical peels, tretinoin or isotretinoin within 4 weeks before the study 5. History of major operation within 1 year 6. History of skin cancer within 1 year 7. Pregnancy or lactation 8. Heavy smoker or drinker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of melanin index day 6, 15 and 29 Corneometer,Quantification of the lightening effect day 6, 15 and 29 chromameter | — |
Secondary
| Measure | Time frame |
|---|---|
| N/A N/A N/A | — |
Countries
Thailand
Contacts
Cosmetics and natural products research center, Faculty of Pharmaceutical Sciences, NU