Safety and Efficacy Determination of Skin Lightening Set Treatment Products for Combination to Oily Skin

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

TCTR

Registry ID

TCTR20190617002

Enrollment

Unknown

Registered

2019-06-17

Start date

2015-09-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Thai female subjects

Interventions

4 test products including

&#45

Whitening facial foam (CWFF) &#45

Whitening Day Cream for Combination to oily skin (CWDO) &#45

Whitening Night Cream for Combination to oily skin (CWNO) &#45

Activating Essence Lotion (CME)

Experimental Other

4 test products

Eligibility

Sex/Gender

Female

Age

25 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1. Healthy female volunteers in an age range of 25-35 years old with combination to oily skin 2. Free of any visible disease on the test area 3. Having dull skin, pigmentary dark sots on the face 4. Having experience using any counter brand product 5. No history of allergy against any components of trial products or other whitening cosmetics 6. Be able to use only provide products (exception for the normal products in other categories of their routine use) during the test period 7. No history of takingany functional supplement which improve skin condition and no skin treatment within 1 month prior the study 8. Be able to follow the study protocol 9. Willing to give a consent of the volunteer

Exclusion criteria

Exclusion criteria: 1. History of eczema or psoriasis within 6 months 2. History of herbes 3. Incident of facial warts, wounds or scars 4. Medical or cosmetic treatment with steroids, antibiotics, NSAIDs, anti-histamine, azelaic acid, kojic acid, hydroquinone, chemical peels, tretinoin or isotretinoin within 4 weeks before the study 5. History of major operation within 1 year 6. History of skin cancer within 1 year 7. Pregnancy or lactation 8. Heavy smoker or drinker

Design outcomes

Primary

Measure	Time frame
Skin irritation test 0, 0.5, 1, 24h 24 hours patch test,Quantification of the lightening effect week 0, 1, 4, 8 chromameter,Quantification of skin moisture week 0, 1, 4, 8 Corneometer,Quantification of melanin index week 0, 1, 4, 8 Mexameter ,Quantification of the Erythema value week 0, 1, 4, 8 Mexameter ,Visual evaluation week 0, 1, 4, 8 Digital photography,Satisfaction of scrub product usage week 1, 4, 8 Questionnaire form,skin type week 8 visual	—

Measure

Time frame

Skin irritation test 0, 0.5, 1, 24h 24 hours patch test,Quantification of the lightening effect week 0, 1, 4, 8 chromameter,Quantification of skin moisture week 0, 1, 4, 8 Corneometer,Quantification of melanin index week 0, 1, 4, 8 Mexameter ,Quantification of the Erythema value week 0, 1, 4, 8 Mexameter ,Visual evaluation week 0, 1, 4, 8 Digital photography,Satisfaction of scrub product usage week 1, 4, 8 Questionnaire form,skin type week 8 visual

—

Secondary

Measure	Time frame
N/A N/A N/A	—

Countries

Thailand

Contacts

Public ContactNeti Waranuch

Cosmetics and natural products research center, Faculty of Pharmaceutical Sciences, NU

cosnat@nu.ac.th+6655968801

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026