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Efficacy of Moraceae with chlorhexidine mouthwash on the microbial flora of critically ill intubated patients

Efficacy of Moraceae with chlorhexidine mouthwash on microbial flora of critically ill intubated patients: a randomized controlled pilot study

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190530003
Enrollment
30
Registered
2019-05-30
Start date
2019-05-30
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ventilator-associated pneumonia is a common bacterial nosocomial infection in the intensive care units. Critically ill patients undergoing tracheal intubation are at high risk for pneumonia due to ora Ventilator associated pneumonia, mouthwash, chlorhexidine, Moraceae

Interventions

Moraceae plus 0.12% chlorexidine mouthwash three times a day for 7 days ,0.12% chlorexidine mouthwash three times a day for 7 days
Experimental Drug,Active Comparator Drug
Moraceae plus chlorhexidine mouthwash ,Chlorhexidine mouthwash

Sponsors

Faculty of Mecicine, Prince of Songkla University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Adults (age more than 18 years) 2. Admitted in the medical intensive care unit within 24 hours 3. Having a tracheal tube and expect to on mechanical ventilation at least 48 hours 4. No contraindication for Moraceae or chlorhexidine mouthwash

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Sensitivity of anaphylaxis to herbal preparation and chlorhexidine

Design outcomes

Primary

MeasureTime frame
Oral microbial flora day 1 and day 4 colony forming unit

Secondary

MeasureTime frame
Oral health day 1-7 modified Beck oral assessment score ,Ventilator associated pneumonia In admission period No of patients ,Adverse events In admission period No of adverse events

Countries

Thailand

Contacts

Public ContactVeerapong Vattanavanit

Prince of Songkla University

vveerapong@gmail.com0848456228

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026