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The Effect of Pretreatment Submucosal Tramadol and Dexamethasone Injection on Postendodontic Pain in Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis: A Randomized Controlled Clinical Trial

The Effect of Pretreatment Submucosal Tramadol and Dexamethasone Injection on Postendodontic Pain in Mandibular Molar Teeth with Symptomatic Irreversible Pulpitis: A Randomized Controlled Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190529001
Enrollment
Unknown
Registered
2019-05-29
Start date
2018-10-20
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postendodontic treatment pain in patients with symptomatic irreversible pulpitis Dexamethasone&#44

Interventions

After administration of local anesthesia and before starting treatment
submucosal 100 mg/2 ml tramadol was administrated to the mucobuccal fold of mandibular molar in tramadol group.,After administration of local anesthesia and before starting treatment
submucosal 8 mg/2 ml dexamethasone was administrated to the mucobuccal fold of mandibular molar in dexamethasone group.,After administration of local anesthesia and before starting treatment
submucosal 2 ml saline were administrated to the mucobuccal fold of mandibular molar in control group.
Experimental Other,Experimental Other,Placebo Comparator Other
Submucosal Tramadol,Submucosal Dexamethasone,Control

Sponsors

none
Lead Sponsor
none,none
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria included systemically healthy patients, aged between 18 and 65 years, having mandibular molars with symptomatic irreversible pulpitis, preoperative pain score ranging from moderate to severe (55–170 mm) on a Heft-Parker visual analog scale (HP-VAS, 0–170 mm), radiographically normal periapical area and no pain on percussion.

Exclusion criteria

Exclusion criteria: The exclusion criteria comprised: pregnant or breastfeeding women, patients with allergy, sensitivity or adverse reactions to the medications administered in this study, those who had taken an analgesic or anti-inflammatory drug within last 12 hours before the treatment, those with unrestorable teeth, teeth with periodontal disease, root resorption, open apex, calcified root canals and pulpal necrosis.

Design outcomes

Primary

MeasureTime frame
controlling of postendodontic pain 6., 12.,24.,48. and 72 hours HP VAS Scale—

Secondary

MeasureTime frame
preparation pain 15 minutes HP VAS Scale—

Countries

Türkiye

Contacts

Public ContactFatih Aksoy

no

dr.f.aksoy@gmail.com+90542 342 88 07

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026