A Comparison of Efficacy between Low-Dose Dexmedetomidine and Propofol for Prophylaxis of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

TCTR

Registry ID

TCTR20190522001

Enrollment

111

Registered

2019-05-22

Start date

2019-05-27

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative delirium Postoperative delirium,Dexmedetomidine, Propofol,Hip surgery

Interventions

Dexmedetomidine (4 mcg/ml) 0.2 mcg/kg/hr IV continuous drip&#44

no bolus dose&#44

max 0.7 mcg/kg/hr,Propofol (10 mg/ml) 0.5 mg/kg/hr (8.3 mcg/kg/min) IV continuous drip&#44

no bolus&#44

max 1.75 mg/kg/hr (29 mcg/kg/min),Normal saline 2.5 ml/hr IV continuous drip

Active Comparator Drug,Active Comparator Drug,Active Comparator Drug

Dexmedetomidine,Propofol,Placebo

Eligibility

Sex/Gender

All

Age

60 Years to 100 Years

Inclusion criteria

Inclusion criteria: - Age 60 years old or older - Admit post-operative in ICU - Closed fracture intertrochanteric or neck of femur - ASA (American Society of Anesthesiologists) class 2-3 - BMI 18 - 40 kg/m2

Exclusion criteria

Exclusion criteria: - Patient refusal - Allergy to drugs used in this research - Richmond Agitation Sedation Scale (RASS) less than - 2 before sedation - Prior delirium or dementia - Prior or acute cerebrovascular disease - Bradycardia eg. Second or Third-degree atrioventricular block - Prior temporary or permanent pacemaker - Bradycardia (HR less than 50 bpm) of different origin - Severe congestive heart failure - Obstructive sleep apnea - Severe chronic obstructive pulmonary disease - Seizure or status epilepticus - Delirium tremens and alcohol withdrawal - Substance abuse with acute experience of acute withdrawal

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative delirium Postoperative period CAM-ICU	—

Secondary

Measure	Time frame
Drugs side effects and complication Postoperative period Medical record,Fentanyl consumption Postoperative period Medical record and recording from patient-controlled analgesia (PCA) machine,Length of hospital stay Postoperative period Medical record,Postoperative Thai Mental State Examination (TMSE) Postoperative period Examine by psychiatrists	—

Countries

Thailand

Contacts

Public ContactGamonmas Ekkapat

Faculty of Medicine, Chulalongkorn University

gamonmas@yahoo.com0894950088

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026