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A randomized non-inferior trial of adductor canal block with iPACK (interspace between the popliteal artery and capsule of the posterior knee) block versus local infiltration analgesia for analgesia after total knee arthroplasty

The comparison of adductor canal block with local anesthetic injection into the interspace between the popliteal artery and posterior capsule of the knee (iPACK) versus local infiltration of analgesia after Total knee arthroplasty: A randomized contr

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190520001
Enrollment
Unknown
Registered
2019-05-20
Start date
2019-05-09
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

OA Knee going on total knee arthroplasty posterior knee pain knee arthroplasty ultrasound&#45

Interventions

guided local anesthetic injection into the interspace between the popliteal artery and posterior capsule of the knee (iPACK) is performed by injecting of 0.25% levobupivacaine 20 ml and adrenaline 0.1
operatively. Continuous adductor canal block under ultrasound guidance is performed postoperatively by injecting 0.25% levobupivacaine 20 ml and followed by 0.15% levobupivacaine 5 ml/hr for 60 hours
guided sham iPACK block is performed by injecting of 0.9% NSS 20 ml. Local infiltration analgesia is performed intra&#45
operatively. The cocktail consists of Levopupivacaine 100 mg&#44
and Adrenaline 0.3 mg combined with NSS 60 ml. Continuous adductor canal block under ultrasound guidance is performed postoperatively by injecting 0.25% levobupivacaine 20 ml and followed by 0.15% le
Experimental Procedure/Surgery,Experimental Procedure/Surgery
Adductor canal block+ iPACK,Local infiltration analgesia

Sponsors

none
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patient who was scheduled for total knee arthroplasty at King Chulalongkorn Memorial Hospital ASA class 1 to 3 ASA class 1 A normal healthy patient ASA class 2 A patient with mild systemic disease Mild diseases only without substantive functional limitations ASA class 3 A patient with severe systemic disease but not threaten to life Body mass index BMI between 18 to 40 kg m2

Exclusion criteria

Exclusion criteria: refuse to participate this study unable to cooperate or cognitive impairment eg dementia allergy to any drug in this study contraindication to neuraxial anesthesia eg coagulopathy contraindication to NSAIDs Ketorolac and Celebrex in this study chronic opioids use or diagnosed of neuropathic pain unable to performed Time up and go test

Design outcomes

Primary

MeasureTime frame
Postoperative pain score 12 hours Visual Analog Scale

Secondary

MeasureTime frame
Postoperative pain score 0, 4, 8, 24, 36 and 48 hours, 2 and 5 days, 2 weeks, 6 weeks and 2 months Visual Analog Scale,postoperative opioid consumption 12, 24, 48 hours Milligram of Morphine Consumption,Quadriceps Strength Postoperative 0, 1, 2, 3 Days Maximum voluntary isometric contraction,Degree of knee flexion (active and passive) Postoperative 0, 1, 2, 3 Days Degree of range of motion,Timed up and go test Postoperative 3 Months Rehabilitation after surgery,Cumulated Ambulation Score Postoperative 0, 1, 2, 3 Days Rehabilitation after surgery,Postoperative Complication Postoperative 0, 1, 2, 3 Days Postoperative Nausea Vomiting, Dizziness, Fall, Sleep disturbance,Length of stay Postoperative to discharge out of hospital hours,Sensory and Motor Function of Tibial Nerve Postoperative 6 hours Plantar Flexion and Cold Sensation of Plantar aspect,Sensory and Motor Function of Common Peroneal Nerve Postoperative 6 hours Dorsiflexion and Cold Sensation at Dorsum aspect,Patient satisfaction Postoperative day 2 Satisfactory score (1-10)

Countries

Thailand

Contacts

Public ContactWannida Kertkiatkachorn

King chulalongkorn memorial hospital

earnearnedearned@hotmail.com+66954672333

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026