Type 1 diabetes mellitus patients have higher of MDA,
Conditions
Interventions
type 1 diabetes mellitus patients which HbA1C > 7% have been treated at Siriraj hospital,Control group is healthy subjects who have age-
matched with Type 1 diabetes mellitus patients
Basic Science,Basic Science
Sponsors
Faculty of Dentistry, Mahidol University
Faculty of Dentistry,
Mahidol University
Eligibility
Sex/Gender
All
Age
15 Years to 22 Years
Inclusion criteria
Inclusion criteria: Type 1 diabetes mellitus patients which HbA1C > 7% have been treated at Siriraj hospital Control group is healthy patients who have age matched with type 1 diabetes mellitus patients
Exclusion criteria
Exclusion criteria: 1. Patient who have been periodontitis as a manifestation of systemic diseases such as Leukocyte adhesion deficiency, Ehler danlos syndrome, neutropenia, Down sysdrome, Papillon Lefvere sysdrome, Chediak Higashi sysdrome, Histiocytosis sysdrome, Glycogen storage disease, Infantile genetic agranulocytosis, Cohen syndrome, Hyphosphatasia, and leukemia 2. Immunodeficiency patients 3. Patients who cannot cooperate due to a lack of psychological or emotional maturity and/or mental physical or medical disability 4. Patients who take medication that effecting periodontium, bleeding disorder, and infection 5. Patients who recieved bisphosphonate 6. Patients who recieved orthodontics treatment 7. Smkoing 8. Pregnant 9. Patients who have deciduous teeth 10. Patients who recieved periodontal treatment within 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| salivary malondialdehyde levels 0 second The absorbance at 532nm using a spectrophotometer,salivary protein carbonyl levels 0 second The absorbance at 375nm using a spectrophotometer,salivary total antioxidant capacity levels 0 second The absorbance at 405nm using a spectrophotometer,salivary total oxidant status levels 0 second The absorbance at 530nm using a spectrophotometer | — |
Secondary
| Measure | Time frame |
|---|---|
| probing depth 0 second millimetre/PCPUNC15, Hu-Friedy,clinical attachment level 0 second millimetre/PCPUNC15, Hu-Friedy,bleeding on probing 10 second observe bleeding after gentle probing/PCPUNC15, Hu-Friedy,plaque index 0 second observe plaque accumulation | — |
Countries
Thailand
Contacts
Public ContactThanwarat Aroonrangsee
Faculty of Dentistry, Mahidol University
Outcome results
None listed