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The effects of 4 mg dexamethasone on swelling, analgesia, mouth opening and quality of life after surgical removal of lower third molar: A split-mouth triple-blind randomized placebo-controlled study

The anti-inflammatory effect of submucosal injection of dexamethasone following the lower third molar surgery: A prospective split-mouth triple-blind randomized placebo-controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190503005
Enrollment
Unknown
Registered
2019-05-03
Start date
2018-03-01
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients who required surgical removal of bilateral lower third molar anti&#45

Interventions

Pre&#45
operative single dose submucosal injection,Pre&#45
operative single dose submucosal injection of either 4mg/ml dexamethasone or 1ml normal saline solution
Experimental Drug,Placebo Comparator Drug
4mg dexamethasone/ml,Normal saline 1ml

Sponsors

Research Institute, Rangsit University
Lead Sponsor
College of Dental Medicine
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: present with bilateral identical lower molar impaction according to Pell-Gregory classification (Pell & Gregory, 1933) healthy patients who categorized in ASA I & ASA II (American Society for Anesthesiologists) free from any systemic or local infection and have not taken anti-inflammatory drugs, steroids, or antibiotics within 2 weeks before the operation

Exclusion criteria

Exclusion criteria: pregnancy lactating women allergy or has an adverse effect from drugs that will be used in this study patients who are unable to provide informed consent

Design outcomes

Primary

MeasureTime frame
Facial swelling and facial dimensions pre-operation, post-operative day 1, 3 and 7 mm/silk thread,Facial swelling and facial dimensions pre-operation, post-operative day 1, 3 and 7 mm/silk thread,Pain intensity Post-operative day 1, 2, 3 and 7 visual analog scale 1-10cm,Mouth opening Pre-operation, post-operative day1 , 3 and 7 mm/ digital calliper—

Secondary

MeasureTime frame
Quality of life Post-operative day 1, 3 and 7 scores/ 2 kinds of Health-related quality of life questionnaires (Modified OHIP, Modified OIDP)—

Countries

Thailand

Contacts

Public ContactLaddawun Sununliganon

Colege of Dental Medicine

laddawan.su@rsu.ac.th0-2997-2200

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Apr 4, 2026