Effect of celastrol on interleukin-8 production and NF-kB activation by human macrophages

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

TCTR

Registry ID

TCTR20190503002

Enrollment

Registered

2019-05-03

Start date

2019-05-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anti-inflammatory effect of celastrol celastrol, macrophage, NF-kB

Interventions

Using whole blood from healthy volunteer for PBMC isolation

Basic Science

Healthy Volunteer

Eligibility

Sex/Gender

All

Age

20 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1 Healthy volunteer, Body weight over 50 kg 2 No smoking No alcoholic Abuse 3 No non-steroidal anti-inflammatory drug NSAIDs at least 7 days before the venous puncture 4 Informed consent

Exclusion criteria

Exclusion criteria: 1 Pt with Chronic disease 2 Anemia DM

Design outcomes

Primary

Measure	Time frame
Anti-inflammatory effect of celastrol on macrophage function 1 day Spectrophotometry, Western Blot	—

Secondary

Measure	Time frame
Effect of celastrol on NF-kB activation end of an experiment Western Blot	—

Countries

Thailand

Contacts

Public ContactNipapan Malisorn

Faculty of Medicine, Thamasat Uiversity

dr.nipapan@gmail.com029269716

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026