mild to moderate persistent allergic rhinitis Allergic rhinitis Zingiber cussumunar Plai nasal cytokine
Conditions
Interventions
1st period takes Plai capsule for 4 weeks and then placebo capsule for 4 weeks on 2nd period with a 2 weeks wash out period,1st period takes placebo capsule then Phlai capsule for 4 weeks and then Pla
Active Comparator Drug,Placebo Comparator Drug
Phlai,Placebo
Sponsors
Faculty of Medicine Thammasat University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: - reflective total 4-nasal symptoms score 2 to 8 per day for 3 consecutive days and score not more than 8 per day - positive skin prick test to aeroallergen at least 1 allergen - stop using antihistamine > 1 week, intranasal corticosteroid > 2 weeks, systemic corticosteroid > 4 weeks
Exclusion criteria
Exclusion criteria: - underlying disease : chronic lung disease, heart disease, renal disease, liver disease - receive immunotherapy - uncontrolled asthma - receive antidepressant, sedative, anxiolytic, opioids, neuroleptic drugs - nasal polyp, nasal septum deviation, acute or chronic rhinosinusitis - pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| effect of phlai capsule on reduction eosinophils and cytokine in nasal mucosa of allergic rhinitis 4 weeks nasal cytology and nasal secretion | — |
Secondary
| Measure | Time frame |
|---|---|
| effect of phlai capsule on total nasal symptom score 4 weeks TNSS | — |
Countries
Thailand
Contacts
Public ContactNitchanan Achararit
Faculty of Medicine Thammasat University
Outcome results
None listed