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Pregnancy outcomes after vaginal probiotic supplementation before frozen embryo transfer: a single-blind randomized controlled study

Pregnancy outcomes after vaginal probiotic supplementation before frozen embryo transfer: a single-blind randomized controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
TCTR
Registry ID
TCTR20190429001
Enrollment
340
Registered
2019-04-29
Start date
2019-08-07
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy outcome after vaginal probiotic supplementation before frozen embryo transfer Lactobacillus spp. Bacterial vaginosis Intravaginal Probiotics IVF frozen-thaw cycles

Interventions

Lactobacillus+estriol 1 tab vaginal supposition on day 0-5 of secretory phase in frozen thaw cycle,Standard treatment of frozen thaw cycle
Experimental Drug,No Intervention No treatment
Lactobacillus acidophilus group,Control group

Sponsors

Siriraj hospital, Mahidol university
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 39 Years

Inclusion criteria

Inclusion criteria: Thai women aged 18-39 years who were attending the frozen-thaw cycles were enrolled.

Exclusion criteria

Exclusion criteria: Women who had 3 or more cycles of implantation failures, thin endometrium, or were allergic to the medicine used in the study group were excluded.

Design outcomes

Primary

MeasureTime frame
Pregnancy rate at 2 weeks after intervention chi square

Secondary

MeasureTime frame
Miscarriage rate, Clinical pregnancy rate, Ongoing pregnancy rate, Live birth rate at 2 weeks after pregnancy confirmed, second trimester and after birth Chi squre

Countries

Thailand

Contacts

Public ContactSootthinan Pothisan

-

sootthinan.pot@gmail.com0894600852

Outcome results

None listed

Source: TCTR (via WHO ICTRP) · Data processed: Aug 9, 2026